RNA Details
Disease Name
silicosis
Tissue
lung
RNA Symbol
Smad3
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay etc.
Target
Myd88; Smad3
Pathway
NA
PubMed ID
Title
MiR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF
Year
2016
Function
"Levels were reduced in both macrophages that were exposed to silica and fibroblasts that were exposed to TGF-B1. MiR-489 inhibited silica-induced pulmonary fibrosis primarily by repressing its target genes MyD88 and Smad3. Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways."